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Product Overview
REJURAN HB is a polynucleotide (PN) and hyaluronic acid (HA) injectable medical device developed by PharmaResearch Co., Ltd. in South Korea. Designed for temporary improvement of adult facial wrinkles through physical tissue restoration, it combines salmon-derived polynucleotides with sodium hyaluronate in a low-viscosity formulation.
REJURAN HB contains 10 mg/mL polynucleotide, 10 mg/mL hyaluronic acid, and 0.3% lidocaine. The formulation integrates the properties of PN and HA, while the incorporated local anesthetic is intended to help reduce injection-related discomfort. Supplied in a 1 mL prefilled syringe, REJURAN HB is intended for use by qualified healthcare professionals.
Key Features
- PN + HA Combination: Combines 10 mg/mL sodium polynucleotide with 10 mg/mL sodium hyaluronate, bringing together a purified DNA-derived polymer and the water-binding properties of hyaluronic acid.
- Salmon-Derived Polynucleotide: Contains purified polynucleotides derived from salmon DNA and processed using PharmaResearch's proprietary DOT™ technology.
- Low-Viscosity Formulation: Classified as a low-viscosity product within PharmaResearch's original REJURAN range, with different physical characteristics from standard REJURAN and the higher-viscosity REJURAN S.
- Pre-Incorporated Lidocaine: The manufacturer's original REJURAN HB documentation identifies 0.3% lidocaine as part of the formulation for improved treatment comfort.
- Convenient Prefilled Syringe: Supplied in a sterile 1 mL prefilled syringe, with one syringe per box for professional single use.
Composition & Specifications
| Product Name | REJURAN HB |
|---|---|
| Manufacturer | PharmaResearch Co., Ltd. |
| Country of Origin | South Korea |
| Product Category | PN + HA Injectable Medical Device |
| Sodium Polynucleotide (PN) | 10 mg/mL (1%) |
| Hyaluronic Acid (HA) | 10 mg/mL (1%), as Sodium Hyaluronate |
| Lidocaine | 0.3% (Manufacturer-Reported) |
| PN Origin | Purified Salmon-Derived DNA |
| PN Processing Technology | DNA Optimizing Technology (DOT™) |
| Formulation | PN + HA Injectable Solution |
| Relative Viscosity | Low |
| Volume per Syringe | 1 mL |
| Packaging | 1 mL × 1 Prefilled Syringe / Box |
| Model Number | ME5-001 |
| Korean Medical Device License | 17-353 |
| Intended Purpose | Temporary Improvement of Adult Facial Wrinkles Through Physical Tissue Restoration |
| Storage Temperature | 1–30°C, Protected from Light |
How REJURAN HB Works
REJURAN HB combines polynucleotide (PN) and hyaluronic acid (HA), two materials with distinct physical and biological properties relevant to skin tissue.
Polynucleotide (PN): PN consists of long-chain molecules formed from repeating nucleotide units. PharmaResearch obtains its PN material from purified salmon DNA using proprietary processing technology. Polynucleotides are hydrophilic polymers studied for their interactions with dermal fibroblasts, extracellular matrix components, and tissue-repair processes.
Hyaluronic Acid (HA): HA is a naturally occurring glycosaminoglycan found throughout the extracellular matrix. Its ability to attract and bind water contributes to skin hydration and tissue viscoelasticity. In REJURAN HB, sodium hyaluronate complements the PN-based formulation by contributing these water-binding properties.
Lidocaine: Lidocaine is an amide-type local anesthetic that reduces nerve signal transmission by blocking voltage-gated sodium channels. Its inclusion in the original REJURAN HB formulation is intended to help reduce discomfort associated with injection.
The mechanisms described above reflect established ingredient properties and related scientific research. They do not independently establish additional clinical indications or guaranteed outcomes for the finished product.
REJURAN HB vs. REJURAN HB PLUS
REJURAN HB and REJURAN HB PLUS are separately documented medical devices within the PharmaResearch product portfolio. Although both are associated with polynucleotide, hyaluronic acid, and lidocaine formulations, they have different Korean medical device registrations, stated intended purposes, and storage requirements.
| Specification | REJURAN HB | REJURAN HB PLUS |
|---|---|---|
| Principal Components | PN + HA + Lidocaine | PN + HA + Lidocaine |
| Lidocaine | 0.3% (Original Manufacturer Brochure) | 0.3% |
| Korean Medical Device License | 17-353 | 21-629 |
| Korean Approved Intended Purpose | Temporary Improvement of Adult Facial Wrinkles | Temporary Improvement of Adult Crow's Feet |
| Storage Temperature | 1–30°C | 2–8°C |
| Packaging | 1 mL × 1 Syringe | 1 mL × 1 Syringe |
The manufacturer's original REJURAN HB brochure identifies lidocaine as an ingredient in REJURAN HB. Therefore, REJURAN HB should not be assumed to be lidocaine-free. Verify the exact product name, composition, and market-specific labeling before professional use.
Storage & Handling
- Storage Temperature: Store REJURAN HB at room temperature between 1°C and 30°C, according to its published instructions for use.
- Light Protection: Keep the product protected from direct sunlight.
- Packaging Integrity: Do not use the product if the original packaging is opened, damaged, or compromised.
- Single Use: The sterile prefilled syringe is intended for one-time use only. Do not reuse or resterilize.
- Professional Handling: Follow the instructions for use and applicable medical device regulations.
REJURAN HB and REJURAN HB PLUS have different published storage requirements. Always follow the labeling accompanying the exact supplied product.
Frequently Asked Questions
What are the main ingredients in REJURAN HB?
REJURAN HB combines sodium polynucleotide (PN) and sodium hyaluronate (HA). Commonly published specifications identify 10 mg/mL PN and 10 mg/mL HA, while the manufacturer's original REJURAN HB brochure also identifies lidocaine at 0.3%.
How is REJURAN HB different from standard REJURAN?
Standard REJURAN is formulated around purified polynucleotide, whereas REJURAN HB combines PN with hyaluronic acid. This provides an additional water-binding component. REJURAN HB is also classified as having lower viscosity than standard REJURAN in the manufacturer's original product comparison.
Does REJURAN HB contain lidocaine?
Yes, the manufacturer's original REJURAN HB brochure identifies 0.3% lidocaine in the formulation, and the Korean REJURAN HB instructions for use also mention lidocaine. REJURAN HB should therefore not be classified as lidocaine-free without confirmation from the manufacturer for the exact supplied version.
Are REJURAN HB and REJURAN HB PLUS interchangeable?
No. REJURAN HB and REJURAN HB PLUS have separate Korean medical device registrations and different published intended purposes and storage conditions. Their similar ingredient profiles do not establish regulatory or clinical interchangeability.
How is REJURAN HB packaged?
REJURAN HB is supplied as one sterile 1 mL prefilled syringe per box. The product is intended for single use by qualified healthcare professionals.