NCTF 135 HA

Product Overview

NCTF 135 HA is a French injectable skin revitalization product developed and manufactured by Laboratoires FILL-MED, formerly associated with Laboratoires FILORGA. The formulation combines 5 mg/mL non-crosslinked hyaluronic acid (HA) with a polyrevitalizing complex containing vitamins, amino acids, coenzymes, nucleic acid-related components, minerals, and other supporting ingredients. Designed for professional aesthetic applications, NCTF 135 HA is intended to improve skin hydration, radiance, texture, and the appearance of superficial wrinkles.

NCTF stands for New Cellular Treatment Factor. Developed from FILLMED's research into skin physiology and cellular metabolism, the NCTF formulation is designed to provide a combination of hydrating and biologically relevant compounds within a single injectable solution.

Unlike conventional cross-linked hyaluronic acid fillers primarily designed for structural volume augmentation, NCTF 135 HA contains non-crosslinked sodium hyaluronate combined with a multi-ingredient revitalizing solution. Its primary aesthetic positioning focuses on skin quality, hydration, superficial wrinkles, and the appearance of aging skin.

The formulation contains 60 listed ingredients, consisting of non-crosslinked HA, 12 vitamins, 24 amino acids, 6 coenzymes, 5 nucleic acid-related compounds, 6 minerals, and 6 additional ingredients.

NCTF 135 HA is supplied in sterile 3 mL glass vials. FILLMED documents two commercial presentations: a professional kit containing five vials with associated sterile accessories and a separate box containing ten vials without the same accessory kit.

This TEOSQUARE product page provides professional buyers with information about NCTF 135 HA's composition, ingredient characteristics, packaging options, storage requirements, intended aesthetic applications, and regulatory considerations.

Key Features

• 5 mg/mL Non-Crosslinked Hyaluronic Acid: Contains non-crosslinked sodium hyaluronate, a hydrophilic glycosaminoglycan associated with tissue hydration and extracellular matrix properties.
• 60-Ingredient Formulation: Combines HA with vitamins, amino acids, coenzymes, nucleic acid-related compounds, minerals, and additional formulation components.
• 12 Vitamins: Includes vitamins A, C, E, several B vitamins, and other vitamin-related compounds involved in cellular metabolism and antioxidant processes.
• 24 Amino Acids: Provides amino acids associated with protein synthesis and biological processes involving connective tissue and extracellular matrix maintenance.
• 6 Coenzymes: Contains coenzyme-related compounds, including NAD, NADP, FAD, CoA, TPP, and UTP, which participate in various cellular biochemical processes.
• Glutathione and Supporting Components: Includes glutathione, a naturally occurring tripeptide involved in cellular redox regulation.
• Skin Revitalization Positioning: Intended for professional aesthetic applications involving skin hydration, radiance, superficial wrinkles, and skin redensification.
• 3 mL Vial Presentations: Available in manufacturer-documented packages containing five or ten 3 mL vials.
• European Medical Device Certification: CE-marked as an injectable medical device, with FILLMED reporting certification under the European Medical Device Regulation in February 2025.

Composition & Specifications

NCTF 135 HA contains non-crosslinked sodium hyaluronate at 5 mg/mL and a polyrevitalizing solution containing multiple classes of biologically relevant compounds.

The manufacturer's ingredient classification comprises 12 vitamins, 24 amino acids, 6 coenzymes, 5 nucleic acid-related components, 6 minerals, and 6 additional ingredients. Together with hyaluronic acid, these categories account for 60 listed ingredients.

Non-Crosslinked Hyaluronic Acid — 5 mg/mL

Hyaluronic acid is a naturally occurring glycosaminoglycan found in the extracellular matrix of connective tissues, including the dermis.

Its molecular structure has a strong affinity for water, contributing to the hydration and viscoelastic characteristics of biological tissues.

NCTF 135 HA contains 5 mg/mL non-crosslinked sodium hyaluronate, equivalent to 15 mg of sodium hyaluronate in each 3 mL vial.

Unlike cross-linked HA fillers, non-crosslinked sodium hyaluronate does not form the same chemically stabilized gel network commonly used for structural facial volume augmentation.

The HA component contributes to the product's hydration-oriented formulation concept and its intended use for improving skin quality and the appearance of superficial wrinkles.

12 Vitamins

The NCTF 135 HA formulation includes 12 vitamins and vitamin-related compounds identified in the manufacturer's instructions for use.

These include ascorbic acid (vitamin C), biotin (vitamin B8), pantothenic acid (vitamin B5), folic acid (vitamin B9), inositol, nicotinamide/nicotinic acid (vitamin B3), pyridoxine/pyridoxal (vitamin B6), riboflavin (vitamin B2), thiamine (vitamin B1), tocopherol (vitamin E), retinol (vitamin A), and vitamin B12.

Vitamins participate in numerous biological processes, including cellular metabolism, antioxidant defense, enzymatic reactions, and tissue maintenance.

Vitamin C is involved in collagen biosynthesis as a cofactor for enzymes participating in collagen maturation. Vitamins C and E also participate in antioxidant-related biochemical processes.

However, the physiological functions of individual vitamins do not independently establish that NCTF 135 HA produces a specific increase in collagen synthesis or antioxidant activity in every patient.

24 Amino Acids

NCTF 135 HA contains 24 amino acids and amino acid-related compounds.

The manufacturer's ingredient list includes alpha-aminobutyric acid, alanine, arginine, asparagine, aspartic acid, cystine, glutamine, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, and valine.

Amino acids are important components of biological proteins and participate in numerous metabolic pathways.

Glycine, proline, and hydroxyproline are particularly relevant to collagen structure, while other amino acids contribute to broader cellular functions.

Their inclusion supports the formulation's nutrient-oriented design, but the presence of amino acids alone does not establish clinically measurable collagen regeneration or improved skin elasticity.

6 Coenzymes

The formulation includes six compounds classified as coenzymes or coenzyme-related substances in FILLMED's product documentation.

These are thiamine pyrophosphate (TPP/cocarboxylase), coenzyme A (CoA), flavin adenine dinucleotide (FAD), nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), and uridine triphosphate (UTP).

Coenzymes and nucleotide-related compounds participate in cellular metabolic reactions.

NAD and NADP are involved in oxidation-reduction reactions, while FAD participates in various metabolic processes associated with cellular energy production.

Coenzyme A is involved in biochemical reactions involving acyl groups and metabolic intermediates.

The inclusion of these substances does not independently establish increased cellular ATP production, enhanced mitochondrial function, or reversal of biological aging following administration of NCTF 135 HA.

5 Nucleic Acid-Related Components

NCTF 135 HA contains five nucleoside-related compounds classified under nucleic acids in the manufacturer's ingredient documentation.

These include deoxyadenosine, deoxycytidine, deoxyguanosine, deoxythymidine, and 5-methyl-2'-deoxycytidine.

Nucleosides and related compounds participate in biological pathways associated with nucleic acid metabolism.

Their presence contributes to the formulation's biochemical composition but does not independently establish enhanced DNA repair, increased cell division, or accelerated tissue regeneration.

6 Minerals

The mineral component consists of calcium chloride, potassium chloride, magnesium sulfate, sodium acetate, sodium chloride, and sodium dihydrogen phosphate.

Mineral ions participate in physiological processes involving electrolyte balance, enzyme activity, cellular signaling, and metabolic regulation.

Their inclusion contributes to the formulation's overall physicochemical and biochemical characteristics.

6 Additional Ingredients

The manufacturer's formula identifies six additional components: glutathione, polysorbate 80, glucuronic acid, glucuronic acid lactone, glucosamine, and anhydrous dextrose.

Glutathione is a naturally occurring tripeptide composed of glutamate, cysteine, and glycine. It participates in intracellular antioxidant and redox-regulation systems.

Glucosamine and glucuronic acid are associated with biological pathways involving glycosaminoglycans and extracellular matrix constituents.

Polysorbate 80 and dextrose are also used in pharmaceutical and medical formulations for supporting physicochemical properties.

The manufacturer's ingredient classification includes both biologically relevant compounds and supporting formulation ingredients. The description of 60 ingredients should not be interpreted as 60 independently validated therapeutic active substances.

How NCTF 135 HA Works

NCTF 135 HA combines non-crosslinked hyaluronic acid with a polyrevitalizing solution containing multiple classes of compounds involved in cellular metabolism and skin physiology.

The manufacturer's formulation concept is based on improving the skin's hydration and supporting biological conditions associated with tissue maintenance and skin quality.

Hyaluronic Acid and Skin Hydration

Hyaluronic acid is a hydrophilic molecule capable of interacting with water within the extracellular matrix.

In the skin, HA contributes to hydration, viscoelasticity, and the physicochemical environment surrounding dermal cells.

NCTF 135 HA incorporates 5 mg/mL non-crosslinked sodium hyaluronate to support its hydration-oriented aesthetic purpose.

Unlike conventional cross-linked HA fillers, the formulation is not primarily designed to provide substantial structural facial projection.

Cellular Metabolism and Nutrient Availability

Normal cellular metabolism requires numerous vitamins, coenzymes, amino acids, minerals, and other biological compounds.

The NCTF polyrevitalizing solution combines several of these ingredient categories in one formulation.

FILLMED describes this approach as supporting a favorable biochemical environment for skin-cell activity.

However, the presence of metabolic substrates and cofactors does not automatically demonstrate increased cellular energy production or improved metabolic performance in human skin.

Fibroblast Activity and Extracellular Matrix

Fibroblasts are connective tissue cells involved in producing collagen, elastin-associated extracellular matrix components, and other structural materials.

The dermal extracellular matrix contributes to skin firmness, elasticity, thickness, and mechanical support.

FILLMED describes NCTF 135 HA as a skin-revitalizing formulation intended to support fibroblast-associated processes and improve skin quality.

Clinical research involving NCTF 135 HA has investigated outcomes including skin hydration, fine lines, radiance, and elasticity.

The degree of improvement depends on the study population, assessment method, treatment conditions, and individual response.

Antioxidant-Related Processes

Oxidative stress involves an imbalance between reactive oxygen species and biological antioxidant defenses.

NCTF 135 HA includes vitamin C, vitamin E, and glutathione, compounds associated with antioxidant-related biochemical processes.

These ingredients provide a scientific rationale for the formulation's antioxidant-oriented design.

Their inclusion does not independently establish that NCTF 135 HA prevents ultraviolet damage, eliminates oxidative stress, or reverses skin aging.

Skin Redensification and Superficial Wrinkles

NCTF 135 HA is intended for improving the appearance of superficial wrinkles and supporting the redensification of mature or lax skin.

The manufacturer identifies skin hydration, texture, radiance, and elasticity among the principal characteristics evaluated in its aesthetic clinical research.

These applications differ from deep structural augmentation performed with conventional cross-linked hyaluronic acid fillers.

The mechanisms above combine established ingredient-level physiology with the manufacturer's intended product characteristics. They should not be interpreted as guarantees of increased collagen synthesis, cellular regeneration, or identical clinical outcomes in every patient.

Intended Aesthetic Applications

NCTF 135 HA is a CE-marked injectable medical device intended for professional aesthetic applications involving skin revitalization and hydration.

FILLMED identifies several principal objectives within the product's intended use.

• Skin Hydration: Intended to improve hydration in skin presenting dryness or dullness.
• Skin Revitalization: Designed for aesthetic improvement of tired-looking or dull skin.
• Superficial Wrinkles: Intended for the correction of fine superficial wrinkles rather than major structural volume deficits.
• Skin Redensification: Positioned for the improvement of skin quality and density-related characteristics in mature or lax skin.
• Skin Radiance and Texture: Intended to improve the appearance of uneven texture and reduced skin radiance.

Manufacturer-Documented Treatment Areas

The manufacturer's instructions for use identify the face, including the periorbital area, neck, décolleté, backs of the hands, and inner arms among the areas addressed by the product.

The manufacturer's European safety and clinical performance documentation specifically identifies the face, neck, and décolleté among its principal intended treatment areas.

Permitted anatomical applications may differ according to the applicable version of the instructions for use and the destination country's regulatory requirements.

These descriptions concern the manufacturer's intended aesthetic applications and do not constitute injection instructions. Clinical suitability and permitted use must be evaluated by qualified healthcare professionals according to current product labeling.

NCTF 135 HA vs. Other FILLMED Formulations

FILLMED markets several products containing hyaluronic acid and revitalizing ingredients. Similar product names do not indicate identical formulations or regulatory classifications.

NCTF 135 HA should be distinguished from the original NCTF 135 formulation, NCTF BOOST 135 HA, and M-HA 10.

NCTF 135 HA

NCTF 135 HA contains 5 mg/mL non-crosslinked sodium hyaluronate combined with the manufacturer's polyrevitalizing ingredient complex.

It is intended for professional injectable aesthetic applications involving skin hydration, revitalization, superficial wrinkles, and skin redensification.

NCTF 135

NCTF 135 is a separate formulation within the NCTF product family.

FILLMED identifies a lower hyaluronic acid concentration for NCTF 135 than for NCTF 135 HA.

Buyers should confirm the complete product name rather than assuming the two formulations have identical HA concentrations.

NCTF BOOST 135 HA

NCTF BOOST 135 HA contains 5 mg/mL hyaluronic acid and a related polyrevitalizing ingredient complex.

However, FILLMED classifies NCTF BOOST 135 HA as a sterile cosmetic intended for topical use.

It must not be confused with NCTF 135 HA, which is a separately classified injectable medical device.

M-HA 10

M-HA 10 is another FILLMED injectable product containing non-crosslinked hyaluronic acid.

Its HA concentration is 10 mg/mL, and its formulation differs from the multi-ingredient NCTF 135 HA complex.

M-HA 10 should therefore be identified as a separate product rather than another packaging configuration of NCTF 135 HA.

This product page covers injectable NCTF 135 HA only. Other FILLMED formulations may have different concentrations, regulatory classifications, permitted applications, and packaging specifications.

Packaging & Product Presentation

NCTF 135 HA is supplied as a sterile liquid solution in 3 mL glass vials.

FILLMED documents two commercial package configurations: a professional kit containing five vials with sterile accessories and a separate ten-vial box.

5 × 3 mL Professional Kit

The five-vial professional kit contains five 3 mL vials of NCTF 135 HA and associated sterile accessories documented in the manufacturer's instructions for use.

The kit includes five 3 mL syringes, five 18G withdrawal needles, five 30G injection needles, and five 32G injection needles.

The total nominal solution volume is 15 mL.

10 × 3 mL Vial Box

The ten-vial presentation contains ten 3 mL vials, providing a total nominal volume of 30 mL.

Unlike the five-vial professional kit, this presentation does not include the same syringe and needle accessories.

FILLMED states that not all packaging configurations are necessarily marketed in every country.

Product Authentication

FILLMED documents an authentication system using a Prooftag label with a unique identification number, QR code, and Bubble Tag security element.

These features allow professional buyers to verify product authenticity using the manufacturer's designated verification process.

Buyers should also confirm the original product name, package configuration, batch number, expiration date, and manufacturer details.

Packaging quantities and accessories are based on manufacturer-documented configurations. The availability of each presentation may differ by destination market. Needle specifications are provided for product identification only and do not constitute administration instructions.

Storage & Handling

FILLMED's official instructions for use specify storage between 2°C and 25°C for NCTF 135 HA.

The product should be stored in a dry environment protected from light and moisture.

• Storage Temperature: Store between 2°C and 25°C.
• Light Protection: Protect the product from direct light.
• Moisture Protection: Maintain the product in a dry storage environment.
• Original Packaging: Keep the product in its original manufacturer packaging until required for professional use.
• Sterile Container Integrity: Do not use products with opened or damaged packaging.
• Single-Use Handling: Do not reuse or resterilize the product or associated single-use accessories.
• Product Traceability: Verify the batch number, expiration date, product identity, and manufacturer authentication information.

The manufacturer warns that product reuse can create risks, including cross-contamination.

Storage conditions for NCTF 135 HA should not be assumed identical to those of other FILLMED products or unrelated hyaluronic acid formulations.

The official storage range is 2–25°C. Product handling and disposal must follow the manufacturer's current instructions for use and applicable professional requirements.

Safety & Regulatory Considerations

NCTF 135 HA is an injectable medical device intended for use by appropriately qualified healthcare professionals.

Its professional use requires evaluation of patient suitability, product-specific contraindications, material compatibility, and potential complications associated with intradermal aesthetic procedures.

Potential Adverse Reactions

The manufacturer's safety information identifies possible transient adverse reactions, including redness, localized inflammation, swelling, bruising, small hematomas, minor bleeding, and temporary discomfort.

Other reported reactions include itching, nodules, hypersensitivity reactions, granulomatous inflammation, and infection.

Serious allergic reactions and other complications are possible, although their frequency varies according to the event and the available clinical and post-market surveillance data.

Contraindications

FILLMED identifies several circumstances in which NCTF 135 HA should not be used.

• Active Skin Conditions: Patients with skin alterations or diseases affecting the intended treatment area.
• Autoimmune Disease or Immunotherapy: Patients with a history of autoimmune disease or those receiving immunotherapy, according to the manufacturer's contraindications.
• Ingredient Hypersensitivity: Patients with known allergies or hypersensitivity to any formulation component.
• Pregnancy and Breastfeeding: Pregnant or breastfeeding women.
• Age Restrictions: Individuals younger than 18 years.

Procedure-Related Precautions

The manufacturer warns against intravascular injection and emphasizes the importance of professional training and appropriate aseptic handling.

Patients receiving anticoagulants or platelet-aggregation inhibitors may have an increased risk of bruising and bleeding associated with injection procedures.

FILLMED also identifies precautions relating to previously treated areas containing permanent filling materials and certain combinations with other aesthetic procedures.

The product should not be assumed compatible with every aesthetic treatment, antiseptic, or medical device.

Ingredient Compatibility

The manufacturer's instructions identify an incompatibility between hyaluronic acid and quaternary ammonium salts, including benzalkonium chloride.

Professional handling must follow the manufacturer-issued compatibility information.

European Regulatory Classification

NCTF 135 HA is classified as a Class III medical device under the European Medical Device Regulation framework.

The product was originally CE-marked under the former European Medical Devices Directive, and FILLMED reports certification under Regulation (EU) 2017/745 in February 2025.

Its European classification concerns an injectable device intended for aesthetic purposes rather than a pharmaceutical product intended to treat a specific disease.

European certification does not automatically establish approval in the United States or other international markets.

US FDA authorization for NCTF 135 HA has not been established. Professional buyers should verify the product's current regulatory status, import eligibility, permitted indications, and lawful distribution requirements in their destination country.

This description is intended for professional product identification and commercial evaluation. It does not provide injection instructions, establish individual patient suitability, replace the manufacturer's instructions for use, or authorize use outside applicable regulatory requirements.

Frequently Asked Questions