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HYARON Prefilled Injection is a South Korean sodium hyaluronate injectable medicine manufactured by Dongkook Pharmaceutical Co., Ltd. Each 2.5 mL prefilled syringe contains 25 mg of sodium hyaluronate, equivalent to 10 mg/mL (1%). HYARON is supplied as a clear, viscous solution in a prefilled syringe system, with documented packages containing five or ten syringes. The product is approved in South Korea for degenerative osteoarthritis of the knee and shoulder periarthritis. Although HYARON is also marketed internationally in aesthetic skincare channels, cosmetic mesotherapy and facial rejuvenation are not established indications under its Korean pharmaceutical registration.
Key Features
- 25 mg Sodium Hyaluronate: Each HYARON prefilled syringe contains 25 mg of sodium hyaluronate in 2.5 mL, providing a concentration of 10 mg/mL (1% w/v).
- Hyaluronic Acid-Based Solution: Sodium hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring glycosaminoglycan with water-binding and viscoelastic properties.
- Ready-to-Use Prefilled Syringe: HYARON is supplied as a clear, viscous solution in a prefilled syringe system. It does not require reconstitution from a powder.
- Five- and Ten-Syringe Packages: Dongkook Pharmaceutical documents 2.5 mL prefilled syringes in packages containing five or ten syringes per box.
- Pharmaceutical Registration: HYARON is registered in South Korea as a prescription medicine for degenerative knee osteoarthritis and shoulder periarthritis. Other uses require separate regulatory and clinical consideration.
Composition & Specifications
| Specification | Details |
|---|---|
| Product Name | HYARON Prefilled Injection |
| Alternative Name | Hyaron Prefilled Inj. |
| Korean Product Name | 히야론프리필드주사 |
| Manufacturer | Dongkook Pharmaceutical Co., Ltd. |
| Country of Origin | Republic of Korea |
| Product Category | Prescription sodium hyaluronate injectable medicine |
| Active Ingredient | Sodium Hyaluronate |
| Active Ingredient Concentration | 10 mg/mL (1% w/v) |
| Active Ingredient per Syringe | 25 mg |
| Listed Excipients | Sodium Chloride, Dibasic Sodium Phosphate Hydrate, Monobasic Sodium Phosphate, Water for Injection |
| Lidocaine | Not included in the registered ingredient composition |
| Dosage Form | Clear, colorless, viscous injectable solution |
| Product Presentation | Prefilled syringe system |
| Volume per Syringe | 2.5 mL |
| Available Package Quantities | 5 or 10 prefilled syringes per box |
| Total Volume — 5 Syringes | 12.5 mL |
| Total Volume — 10 Syringes | 25 mL |
| Korean Pharmaceutical Classification | Prescription medicine |
| ATC Classification | M09AX01 — Hyaluronic Acid |
| Korean Product Approval Date | October 27, 1993 |
| Korean Product Registration Code | 199300108 |
| Approved Korean Indications | Degenerative osteoarthritis of the knee and shoulder periarthritis |
| Storage Temperature | 1–30°C (34–86°F); protect from light |
| Manufacturer-Listed Shelf Life | 36 months from manufacture |
Specifications refer to Dongkook Pharmaceutical's registered HYARON Prefilled Injection. The product is distinct from HYARON First, HYARON L and similarly named sodium hyaluronate injections manufactured by other companies. Confirm the exact product name, original carton, package quantity and current prescribing information before procurement.
How Sodium Hyaluronate Works
Sodium hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring glycosaminoglycan found in connective tissues, skin and synovial fluid. Its molecular structure allows it to interact with water and contribute to tissue hydration and viscoelasticity.
Within synovial fluid, hyaluronic acid contributes to the lubrication and mechanical properties of joints. Injectable sodium hyaluronate preparations are used in viscosupplementation to help address symptoms associated with certain degenerative joint conditions.
HYARON contains sodium hyaluronate at a concentration of 10 mg/mL. Its registered formulation is a viscous aqueous solution rather than a conventional cross-linked HA volumizing dermal filler. The product's rheological characteristics and labeled indications should therefore not be treated as equivalent to those of cross-linked facial fillers.
Hyaluronic acid is also widely used in topical cosmetics and aesthetic products because of its moisture-binding properties. However, these general ingredient characteristics do not establish that HYARON injections are clinically proven to improve facial wrinkles, skin elasticity, pigmentation or other cosmetic outcomes.
Product Presentation
HYARON Prefilled Injection contains 25 mg of sodium hyaluronate in each 2.5 mL syringe. Dongkook Pharmaceutical documents two package configurations: five or ten syringes per box.
| Presentation | Syringe Volume | HA Content | Package Quantity |
|---|---|---|---|
| HYARON 5-Syringe Pack | 2.5 mL | 25 mg per syringe | 5 syringes per box |
| HYARON 10-Syringe Pack | 2.5 mL | 25 mg per syringe | 10 syringes per box |
These presentations differ in package quantity, not in sodium hyaluronate concentration or individual syringe volume. The actual commercial configuration must be verified against the selected SKU.
Professional Product Selection Considerations
Professional buyers evaluating HYARON should verify its pharmaceutical identity, sodium hyaluronate concentration, syringe volume, package quantity and authorized clinical indications. Its appearance in international aesthetic product catalogs does not change its registered pharmaceutical classification.
- Confirm the Manufacturer: HYARON Prefilled Injection is manufactured by Dongkook Pharmaceutical. Products with similar names from other manufacturers should not be assumed to have identical regulatory registrations.
- Verify Sodium Hyaluronate Content: The registered concentration is 10 mg/mL, equivalent to 25 mg per 2.5 mL syringe. The concentration must not be confused with the total amount of active ingredient per syringe.
- Select the Correct Package: HYARON is documented in five- and ten-syringe boxes. Confirm the actual quantity, carton labeling and expiration date of the selected commercial product.
- Distinguish from Dermal Fillers: HYARON is a sodium hyaluronate injectable solution. It should not be represented as a cross-linked HA facial filler with established volumizing indications.
- Review Authorized Applications: Korean registration covers degenerative knee osteoarthritis and shoulder periarthritis. Cosmetic injection or mesotherapy claims require separate evidence and appropriate authorization.
Storage & Handling
Dongkook Pharmaceutical specifies storage at 1–30°C (34–86°F) in a tightly closed container, protected from light. The manufacturer lists a shelf life of 36 months from the manufacturing date.
Maintain the labeled storage conditions during warehousing and distribution. Check the original packaging, batch identification and expiration date before use. Do not use products with damaged packaging or compromised container integrity.
HYARON is a prescription injectable medicine intended for administration by appropriately qualified healthcare professionals. The Korean prescribing information identifies contraindications and precautions involving hypersensitivity, joint-area infection and certain underlying medical conditions.
Reported adverse reactions include injection-site pain, swelling, redness, warmth and other local inflammatory responses. Serious hypersensitivity reactions may also occur. Healthcare professionals must review the complete product-specific prescribing information before use.
HYARON is not authorized for every application described by international aesthetic product retailers. Follow the current official labeling and destination-market pharmaceutical regulations.
Frequently Asked Questions
What is the main ingredient in HYARON?
HYARON contains sodium hyaluronate, the sodium salt of hyaluronic acid. Each 2.5 mL prefilled syringe contains 25 mg, equivalent to a concentration of 10 mg/mL.
Who manufactures HYARON?
HYARON Prefilled Injection is manufactured by Dongkook Pharmaceutical Co., Ltd., a South Korean pharmaceutical company. The product is registered in South Korea as a prescription medicine.
How many syringes are included in one HYARON box?
Dongkook Pharmaceutical documents packages containing five or ten prefilled syringes. Each syringe contains 2.5 mL of solution with 25 mg of sodium hyaluronate.
Does HYARON contain lidocaine?
No lidocaine is listed in the registered HYARON Prefilled Injection composition. The documented excipients include sodium chloride, sodium phosphate compounds and water for injection.
Is HYARON a cross-linked HA dermal filler?
HYARON is registered as a sodium hyaluronate injectable solution for specified joint conditions, not as a conventional cross-linked HA volumizing dermal filler. The two product categories have different intended applications and regulatory considerations.
Is HYARON approved as a facial skin booster in South Korea?
The Korean pharmaceutical registration identifies degenerative knee osteoarthritis and shoulder periarthritis as approved indications. Cosmetic facial injection, mesotherapy and skin rejuvenation are not established approved indications under that registration.
How should HYARON be stored?
HYARON should be stored at 1–30°C in a tightly closed container protected from light. Dongkook Pharmaceutical lists a shelf life of 36 months from manufacture. Follow the original carton for the applicable expiration date.